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Introduction

As the population ages, the number of geriatric patients requiring medication continues to rise. Geriatric patients often have multiple comorbidities and altered physiology, making drug dosing challenging. Pharmacokinetic-pharmacodynamic (PK-PD) modeling is a valuable tool that can be used to optimize dosing regimens for this vulnerable population. This thesis explores the use of PK-PD modeling in the optimization of dosing regimens for geriatric patients.

1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Pharmacokinetics in geriatric patients
2.2 Pharmacodynamics in geriatric patients
2.3 PK-PD modeling
2.4 Dosing regimens in geriatric patients
2.5 Challenges in dosing optimization for geriatric patients
2.6 Current practices in dosing optimization
2.7 Case studies using PK-PD modeling in geriatric patients
2.8 Ethical considerations in dosing optimization for geriatric patients
2.9 Future directions in dosing optimization for geriatric patients
2.10 Gaps in the literature

Chapter 3: Research Methodology
3.1 Study design
3.2 Sample selection
3.3 Data collection
3.4 PK-PD modeling techniques
3.5 Statistical analysis
3.6 Ethical considerations
3.7 Validation of model
3.8 Sensitivity analysis

Chapter 4: Discussion of Findings
4.1 PK-PD modeling in dosing optimization
4.2 Impact of comorbidities on dosing regimens
4.3 Individualized dosing for geriatric patients
4.4 Adverse drug reactions in geriatric patients
4.5 Comparison of different modeling techniques
4.6 Clinical implications of dosing optimization
4.7 Limitations of the study
4.8 Future research directions

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for clinical practice
5.3 Recommendations for future research
5.4 Conclusion

Thesis Overview

The aging population presents unique challenges in terms of drug dosing due to changes in physiology and comorbidities. Geriatric patients are often prescribed multiple medications, increasing the risk of adverse drug reactions and drug interactions. Pharmacokinetic-pharmacodynamic (PK-PD) modeling offers a systematic approach to optimizing dosing regimens for this vulnerable population.

This thesis aims to explore the use of PK-PD modeling in the optimization of dosing regimens for geriatric patients. The literature review will examine current practices in dosing optimization, challenges in dosing geriatric patients, and ethical considerations. The research methodology will detail the study design, sample selection, data collection, modeling techniques, and statistical analysis. The discussion of findings will present the results of the PK-PD modeling and their implications for clinical practice. The conclusion will summarize key findings, provide recommendations for future research, and conclude the study on exploring the use of PK-PD modeling in the optimization of dosing regimens for geriatric patients.

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