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Introduction

Evaluation of drug-induced cardiotoxicity is an important area of research in the field of pharmacology and cardiology. Cardiotoxicity refers to the detrimental effects of drugs on the heart, leading to various cardiac dysfunctions such as arrhythmias, myocardial infarction, and heart failure. Drug-induced cardiotoxicity is a major concern in the development and use of pharmaceuticals, as it can have serious implications for patient safety and health outcomes. Therefore, it is essential to evaluate the cardiotoxic effects of drugs during preclinical and clinical stages of drug development.

This thesis aims to provide a comprehensive evaluation of drug-induced cardiotoxicity, focusing on the mechanisms and risk factors associated with this adverse drug reaction. The study will also assess current methods for predicting and monitoring cardiotoxicity, as well as potential strategies for mitigating the adverse effects of drugs on the heart.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of drug-induced cardiotoxicity
2.2 Mechanisms of drug-induced cardiotoxicity
2.3 Risk factors for drug-induced cardiotoxicity
2.4 Methods for predicting cardiotoxicity
2.5 Monitoring of drug-induced cardiotoxicity
2.6 Strategies for mitigating cardiotoxic effects
2.7 Examples of drugs associated with cardiotoxicity
2.8 Regulatory guidelines for assessing cardiotoxicity
2.9 Future directions in research on drug-induced cardiotoxicity
2.10 Summary of literature review

Chapter 3: Research Methodology
3.1 Research design
3.2 Study population
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Variables and measurements
3.6 Ethical considerations
3.7 Validity and reliability of study
3.8 Limitations of research methodology

Chapter 4: Discussion of Findings
4.1 Overview of study results
4.2 Comparison with existing literature
4.3 Implications of study findings
4.4 Recommendations for future research
4.5 Practical applications of research
4.6 Strengths and limitations of study

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Conclusion
5.3 Recommendations for practice
5.4 Recommendations for future research
5.5 Limitations of study
5.6 Implications for healthcare policy

In conclusion, this thesis will provide valuable insights into the evaluation of drug-induced cardiotoxicity, with the aim of improving the safety and efficacy of pharmaceuticals in clinical practice. By examining the mechanisms and risk factors associated with drug-induced cardiotoxicity, as well as current methods for predicting and monitoring this adverse drug reaction, the study will contribute to the advancement of knowledge in this important research area.

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