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Introduction

The development of drug-eluting stents has revolutionized the field of interventional cardiology by significantly reducing the incidence of restenosis following percutaneous coronary interventions. These innovative devices have the ability to release anti-proliferative drugs directly into the arterial wall, preventing the re-growth of smooth muscle cells that often leads to blockages in the coronary arteries. Despite their widespread use and success, there are still many challenges and limitations that need to be addressed in order to optimize the performance of drug-eluting stents.

In this thesis, we will delve into the various aspects of the development of drug-eluting stents, including their background, the current problems in the field, the objectives of our study, the limitations we encountered, the scope of our research, the significance of our findings, and the structure of the thesis. Additionally, we will provide definitions of key terms to ensure a clear understanding of the topic.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 History of drug-eluting stents
2.2 Mechanisms of action
2.3 Types of drug-eluting stents
2.4 Drug-eluting stents versus bare-metal stents
2.5 Clinical outcomes
2.6 Complications and issues
2.7 Drug coatings and release kinetics
2.8 Future developments
2.9 Current guidelines and recommendations
2.10 Gaps in the literature

Chapter 3: Research Methodology
3.1 Research design
3.2 Data collection methods
3.3 Study population
3.4 Inclusion and exclusion criteria
3.5 Variables and measurements
3.6 Data analysis techniques
3.7 Ethical considerations
3.8 Limitations of the study

Chapter 4: Discussion of Findings
4.1 Analysis of the data
4.2 Comparison with previous studies
4.3 Interpretation of results
4.4 Implications for practice
4.5 Recommendations for future research
4.6 Limitations of the study
4.7 Strengths of the study
4.8 Conclusion

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Achievements of the study
5.3 Implications for the field
5.4 Recommendations for further research
5.5 Conclusion

Thesis Overview:

The development of drug-eluting stents has been a significant advancement in interventional cardiology, offering a promising solution to the problem of restenosis following coronary interventions. However, there are still various challenges and issues that need to be addressed in order to improve the effectiveness and safety of these devices.

In this thesis, we aim to provide a comprehensive overview of the development of drug-eluting stents, from their historical background to the current clinical outcomes and future prospects. We will conduct a thorough literature review to examine the mechanisms of action, types of drug-eluting stents, clinical outcomes, complications, drug coatings, and release kinetics, as well as gaps in the existing literature. Additionally, we will outline our research methodology, including the study design, data collection methods, analysis techniques, and ethical considerations.

Through our discussion of the findings, we will analyze and interpret the data collected, compare our results with previous studies, and provide recommendations for practice and further research. We will also highlight the limitations and strengths of our study, as well as its implications for the field of interventional cardiology.

In conclusion, this thesis aims to contribute to the current knowledge of drug-eluting stents and provide valuable insights for future research in this important area of cardiovascular medicine.

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