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Introduction

Cancer remains one of the leading causes of death worldwide, with chemotherapy being one of the most common treatment modalities. However, one of the major challenges in the successful treatment of cancer is the development of chemotherapy resistance. Drug transporters play a crucial role in this resistance by affecting the intracellular concentration of chemotherapeutic agents. Understanding the role of drug transporters in chemotherapy resistance is essential for developing strategies to overcome this challenge and improve the efficacy of cancer treatment.

1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter Two: Literature Review
– Overview of cancer chemotherapy
– Mechanisms of chemotherapy resistance
– Role of drug transporters in chemotherapy resistance
– Types of drug transporters involved
– Regulation of drug transporters
– Strategies to overcome chemotherapy resistance
– Current research on drug transporters in chemotherapy resistance
– Clinical implications of drug transporters in chemotherapy resistance
– Future directions in research on drug transporters in chemotherapy resistance
– Gaps in the current literature

Chapter Three: Research Methodology
– Research design
– Study population
– Data collection methods
– Data analysis techniques
– Ethical considerations
– Limitations of the study
– Pilot study
– Validation of data
– Tools and software used

Chapter Four: Discussion of Findings
– Overview of research findings
– Comparison with existing literature
– Implications for clinical practice
– Recommendations for future research
– Strengths and limitations of the study
– Contribution to the field of oncology

Chapter Five: Conclusion and Summary
– Summary of key findings
– Implications for clinical practice
– Recommendations for future research
– Conclusion

Thesis Overview:

The Role of drug transporters in chemotherapy resistance is a crucial area of research in oncology. Chemotherapy resistance remains a significant challenge in the treatment of cancer, leading to treatment failure and disease progression. Drug transporters play a vital role in mediating resistance by influencing the intracellular concentration of chemotherapeutic agents. This thesis aims to explore the role of drug transporters in chemotherapy resistance and their impact on treatment outcomes.

The literature review will provide a comprehensive overview of the current understanding of drug transporters in chemotherapy resistance, including the mechanisms involved, types of drug transporters, regulation, and strategies to overcome resistance. The research methodology will outline the study design, data collection methods, and analysis techniques used to investigate the role of drug transporters in chemotherapy resistance.

The discussion of findings will present the results of the study, compare them with existing literature, and discuss the implications for clinical practice. The conclusion will summarize the key findings, provide recommendations for future research, and highlight the contribution of this study to the field of oncology. Overall, this thesis aims to shed light on the importance of drug transporters in chemotherapy resistance and provide insights into potential strategies to improve treatment outcomes for cancer patients.

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