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Introduction

Cancer remains a leading cause of death worldwide, with an estimated 9.6 million deaths attributed to the disease in 2018 (World Health Organization, 2018). Cancer therapy, including chemotherapy, targeted therapy, and immunotherapy, has significantly improved patient outcomes; however, drug resistance remains a major challenge in the treatment of cancer. Mechanisms of drug resistance in cancer therapy are complex and multifaceted, involving a range of cellular processes that allow cancer cells to evade the effects of chemotherapy drugs. Understanding these mechanisms is crucial for developing new strategies to overcome drug resistance and improve patient outcomes.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of drug resistance in cancer therapy
2.2 Mechanisms of drug resistance
2.3 Cellular processes involved in drug resistance
2.4 Resistance to chemotherapy drugs
2.5 Resistance to targeted therapy
2.6 Resistance to immunotherapy
2.7 Biomarkers of drug resistance
2.8 Strategies to overcome drug resistance
2.9 Clinical implications of drug resistance
2.10 Future directions in drug resistance research

Chapter 3: Research Methodology
3.1 Research design
3.2 Study population
3.3 Data collection methods
3.4 Data analysis
3.5 Ethical considerations
3.6 Variables
3.7 Statistical analysis
3.8 Research limitations

Chapter 4: Discussion of Findings
4.1 Overview of study findings
4.2 Mechanisms of drug resistance identified
4.3 Implications for cancer therapy
4.4 Limitations of the study
4.5 Future research directions

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Conclusion
5.3 Recommendations for future research
5.4 Implications for clinical practice
5.5 Contributions to the field

Thesis Overview

Mechanisms of drug resistance in cancer therapy are a critical issue in oncology, impacting patient outcomes and treatment strategies. This thesis aims to explore the complex mechanisms underlying drug resistance in cancer therapy and provide insights into potential strategies to overcome resistance. The introduction highlights the significance of the study, outlining the background, problem statement, objectives, limitations, and scope of the research. The literature review examines current knowledge on drug resistance mechanisms, including cellular processes, biomarkers, and strategies to overcome resistance. The research methodology details the study design, population, data collection methods, and analysis techniques. The discussion of findings presents the study’s results, implications for cancer therapy, and future research directions. The conclusion summarizes key findings, provides recommendations for future research, and discusses the implications for clinical practice. Through this comprehensive exploration of drug resistance mechanisms in cancer therapy, this thesis aims to contribute to the field and improve patient outcomes.

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