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Introduction:

Drug resistance is a major obstacle in the treatment of various infectious diseases, cancer, and other medical conditions. One of the mechanisms by which microorganisms and cancer cells develop resistance to drugs is through the overexpression of drug efflux pumps. These pumps actively transport drugs out of the cells, reducing their effective concentration and rendering them ineffective in treating the disease.

The Role of drug efflux pumps in drug resistance has been studied extensively in recent years, with researchers aiming to understand the mechanisms by which these pumps confer resistance and to develop strategies to overcome this resistance. This thesis aims to provide a comprehensive overview of the role of drug efflux pumps in drug resistance, focusing on both microbial and cancer cells.

Table of Contents:

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of drug resistance mechanisms
2.2 Drug efflux pumps and their classification
2.3 Mechanisms of drug efflux pump-mediated resistance
2.4 Regulation of drug efflux pumps
2.5 Clinical significance of drug efflux pumps in microbial infections
2.6 Clinical significance of drug efflux pumps in cancer
2.7 Strategies to overcome drug efflux pump-mediated resistance
2.8 Current research on drug efflux pumps
2.9 Gaps in the literature
2.10 Conclusion

Chapter 3: Research Methodology
3.1 Research design
3.2 Study population
3.3 Data collection methods
3.4 Data analysis
3.5 Ethical considerations
3.6 Statistical analysis
3.7 Laboratory techniques
3.8 Limitations of the study

Chapter 4: Discussion of Findings
4.1 Overview of findings
4.2 Comparison with existing literature
4.3 Implications of the findings
4.4 Future research directions
4.5 Strengths and limitations of the study

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Contributions to the field
5.3 Implications for clinical practice
5.4 Recommendations for future research
5.5 Conclusion

Thesis Overview:

Drug resistance is a growing concern in the field of medicine, with the overexpression of drug efflux pumps playing a significant role in this phenomenon. This thesis aims to provide a comprehensive overview of the Role of drug efflux pumps in drug resistance, focusing on both microbial and cancer cells. The literature review explores the various mechanisms by which drug efflux pumps confer resistance, the clinical significance of these pumps, and current research on strategies to overcome resistance. The research methodology outlines the design of the study, data collection methods, and statistical analysis. The discussion of findings analyzes the results of the study in relation to existing literature and addresses implications for future research. The conclusion and summary highlight the key findings of the thesis and provide recommendations for clinical practice and future research. Overall, this thesis aims to contribute to the understanding of drug efflux pump-mediated resistance and to the development of effective strategies to combat this phenomenon.

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