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Introduction

Autophagy is a cellular process that plays a crucial role in maintaining cellular homeostasis by degrading and recycling damaged organelles and proteins. It has been implicated in various physiological and pathological conditions, including cancer. Drug resistance is a major challenge in cancer treatment, leading to treatment failure and disease progression. Emerging evidence suggests that autophagy plays a significant role in the development of drug resistance in cancer cells.

This thesis focuses on exploring the role of autophagy in drug resistance in cancer. The study aims to investigate the mechanisms by which autophagy contributes to drug resistance and explore potential therapeutic strategies targeting autophagy to overcome resistance. Understanding the interplay between autophagy and drug resistance may lead to the development of novel treatment approaches for cancer patients.

Table of Contents

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of autophagy
2.2 Autophagy and cancer
2.3 Autophagy and drug resistance
2.4 Mechanisms of autophagy in drug resistance
2.5 Regulation of autophagy in cancer cells
2.6 Targeting autophagy for cancer therapy
2.7 Clinical implications of autophagy modulation
2.8 Autophagy inhibitors in cancer treatment
2.9 Autophagy activators in cancer treatment
2.10 Future perspectives

Chapter 3: Research Methodology
3.1 Research design
3.2 Study population
3.3 Data collection methods
3.4 Data analysis
3.5 Experimental models
3.6 Autophagy assays
3.7 Drug resistance assays
3.8 Statistical analysis

Chapter 4: Discussion of Findings
4.1 Role of autophagy in drug resistance
4.2 Mechanisms of autophagy-mediated drug resistance
4.3 Therapeutic targeting of autophagy in drug-resistant cancer
4.4 Challenges and limitations
4.5 Future directions

Chapter 5: Conclusion and Summary
5.1 Summary of findings
5.2 Implications of the study
5.3 Recommendations for future research
5.4 Conclusion

Thesis Overview on Role of Autophagy in Drug Resistance

The Role of autophagy in drug resistance is a critical area of research in cancer biology. Drug resistance remains a major obstacle in the treatment of cancer patients, leading to treatment failure and disease progression. Understanding the mechanisms by which cancer cells develop resistance to anticancer drugs is essential for improving treatment outcomes. Autophagy has emerged as a key player in drug resistance, with growing evidence suggesting its involvement in chemoresistance.

This thesis aims to provide a comprehensive overview of the role of autophagy in drug resistance in cancer. The study will explore the molecular mechanisms underlying autophagy-mediated drug resistance and investigate novel therapeutic strategies targeting autophagy to overcome resistance. By integrating knowledge from basic research to clinical applications, this study will contribute to the development of more effective treatment approaches for drug-resistant cancers.

Overall, this thesis will shed light on the intricate relationship between autophagy and drug resistance, providing valuable insights for future research and clinical practice. The findings of this study may pave the way for the development of innovative therapeutic interventions that can improve the outcomes of cancer patients facing drug resistance.

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