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Introduction

Parkinson’s disease is a neurodegenerative disorder characterized by motor symptoms such as tremors, bradykinesia, and rigidity. Recent research has shown that there is a link between Parkinson’s disease and alterations in neurovascular coupling, the process by which blood flow is regulated to match the metabolic demands of neurons. Dysfunction in neurovascular coupling can lead to decreased oxygen and nutrient delivery to the brain, which may contribute to the progression of Parkinson’s disease.

This thesis aims to investigate the relationship between neurovascular coupling and Parkinson’s disease, with a focus on understanding the underlying mechanisms and potential therapeutic targets. By examining the role of neurovascular coupling in the pathophysiology of Parkinson’s disease, this study seeks to provide insights that could lead to the development of novel treatment strategies for this debilitating condition.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of Parkinson’s disease
2.2 Neurovascular coupling and its role in brain function
2.3 Neurovascular coupling in neurodegenerative diseases
2.4 Current understanding of neurovascular coupling in Parkinson’s disease
2.5 Emerging research on neurovascular coupling in Parkinson’s disease
2.6 Therapeutic strategies targeting neurovascular coupling in neurological disorders
2.7 Experimental models of Parkinson’s disease for studying neurovascular coupling
2.8 Imaging techniques for assessing neurovascular coupling
2.9 Biomarkers for monitoring neurovascular coupling in Parkinson’s disease
2.10 Gaps in current knowledge and areas for further research

Chapter 3: Research Methodology
3.1 Research design
3.2 Study population
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Ethical considerations
3.6 Statistical considerations
3.7 Study variables
3.8 Instruments and tools
3.9 Timeline for research
3.10 Anticipated challenges and mitigation strategies

Chapter 4: Discussion of Findings
4.1 Overview of study findings
4.2 Relationship between neurovascular coupling and Parkinson’s disease
4.3 Mechanisms underlying neurovascular dysfunction in Parkinson’s disease
4.4 Implications for the treatment of Parkinson’s disease
4.5 Comparison with existing literature
4.6 Strengths and limitations of the study
4.7 Future directions for research
4.8 Potential clinical applications

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Contributions to the field
5.3 Implications for clinical practice
5.4 Recommendations for further research
5.5 Conclusion

Thesis Overview: Neurovascular coupling in Parkinson’s disease is a complex and multifaceted topic that holds great promise for advancing our understanding of the pathophysiology of this debilitating condition. This thesis will explore the current state of knowledge on neurovascular coupling in Parkinson’s disease, with a focus on elucidating the mechanisms underlying the dysfunction of this process in the context of the disease. By conducting a comprehensive literature review, utilizing advanced research methodologies, and engaging in a rigorous analysis of findings, this study aims to shed light on the potential therapeutic targets that could be exploited to develop novel treatments for Parkinson’s disease. The ultimate goal of this thesis is to provide valuable insights that could lead to improved patient outcomes and quality of life for individuals living with Parkinson’s disease.

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