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Introduction

Fibromyalgia is a complex chronic pain syndrome characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive impairment. Despite its high prevalence and significant impact on patients’ quality of life, the exact etiology of fibromyalgia remains poorly understood. One emerging area of research that has gained increasing attention in recent years is the role of neuroinflammation in the pathogenesis of fibromyalgia.

Neuroinflammation refers to the inflammation of the nervous system, including activation of microglia and astrocytes, release of pro-inflammatory cytokines, and disruption of the blood-brain barrier. In the context of fibromyalgia, neuroinflammation has been implicated in the generation and maintenance of chronic pain, as well as in the development of associated symptoms such as fatigue and cognitive dysfunction.

This thesis aims to provide a comprehensive review of the current literature on neuroinflammation in fibromyalgia, with a focus on the potential mechanisms underlying neuroinflammatory processes, the evidence linking neuroinflammation to fibromyalgia symptoms, and the implications for treatment and management strategies.

Table of Contents

Chapter 1: Introduction
1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Overview of Fibromyalgia
2.2 Neuroinflammation in Chronic Pain
2.3 Neuroinflammatory Pathways
2.4 Biomarkers of Neuroinflammation in Fibromyalgia
2.5 Imaging Studies of Neuroinflammation in Fibromyalgia
2.6 Animal Models of Neuroinflammation in Fibromyalgia
2.7 Neuroinflammation and Fibromyalgia Symptoms
2.8 Neuroinflammation and Comorbidities in Fibromyalgia
2.9 Neuroinflammation and Treatment Strategies
2.10 Gaps in Current Knowledge

Chapter 3: Research Methodology
3.1 Research Design
3.2 Participants
3.3 Data Collection Methods
3.4 Data Analysis Procedures
3.5 Ethical Considerations
3.6 Validity and Reliability
3.7 Research Limitations
3.8 Future Research Directions

Chapter 4: Discussion of Findings
4.1 Overview of Key Findings
4.2 Implications for Clinical Practice
4.3 Theoretical and Practical Contributions
4.4 Comparison with Existing Literature
4.5 Strengths and Limitations of the Study
4.6 Suggestions for Future Research

Chapter 5: Conclusion and Summary
5.1 Summary of Key Findings
5.2 Implications for Fibromyalgia Management
5.3 Recommendations for Clinical Practice
5.4 Contributions to the Field
5.5 Concluding Remarks

Overall, this thesis seeks to advance our understanding of the role of neuroinflammation in fibromyalgia and its implications for clinical practice and future research directions. By synthesizing the existing literature on this topic and presenting original research findings, this thesis aims to contribute to the growing body of knowledge on fibromyalgia pathophysiology and treatment.

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