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Introduction

Pharmacological modulation of epigenetic mechanisms has emerged as a promising approach for the treatment of various diseases, including cancer, neurological disorders, and autoimmune diseases. Epigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding RNAs, play a critical role in the regulation of gene expression and cellular functions. Dysregulation of these mechanisms has been implicated in the pathogenesis of many diseases, making them attractive targets for pharmacological intervention.

This thesis aims to provide a comprehensive overview of the current state of knowledge in the field of pharmacological modulation of epigenetic mechanisms. It will explore the potential of epigenetic-targeted therapies in the treatment of various diseases and discuss the challenges and opportunities in this rapidly evolving field.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of epigenetic mechanisms
2.2 Pharmacological agents targeting DNA methylation
2.3 Pharmacological agents targeting histone modifications
2.4 Pharmacological agents targeting non-coding RNAs
2.5 Epigenetic-targeted therapies in cancer
2.6 Epigenetic-targeted therapies in neurological disorders
2.7 Epigenetic-targeted therapies in autoimmune diseases
2.8 Challenges in developing epigenetic-targeted therapies
2.9 Opportunities for future research
2.10 Summary of the literature review

Chapter 3: Research Methodology
3.1 Research design
3.2 Study population
3.3 Data collection methods
3.4 Data analysis
3.5 Ethical considerations
3.6 Validity and reliability
3.7 Limitations of the methodology
3.8 Future research directions

Chapter 4: Discussion of Findings
4.1 Overview of the findings
4.2 Implications of the findings
4.3 Comparison with existing literature
4.4 Potential mechanisms of action
4.5 Clinical implications
4.6 Future perspectives
4.7 Strengths and limitations of the study

Chapter 5: Conclusion and Summary
5.1 Summary of the key findings
5.2 Implications for future research
5.3 Recommendations for clinical practice
5.4 Concluding remarks

Overall, this thesis will provide a comprehensive overview of the current state of knowledge in the field of pharmacological modulation of epigenetic mechanisms, with a focus on the potential of epigenetic-targeted therapies in the treatment of various diseases. It will also highlight the challenges and opportunities in this rapidly evolving field and provide recommendations for future research and clinical practice.

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