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Introduction

Migraine is a complex neurological disorder characterized by recurrent episodes of severe headaches, often accompanied by other symptoms such as nausea, vomiting, and heightened sensitivity to light and sound. It is estimated that migraine affects over one billion people worldwide, making it one of the most common and disabling neurological disorders. Despite its prevalence, the exact neurobiological mechanisms underlying migraine remain poorly understood. This thesis aims to explore the neurobiology of migraine and primary headaches, with the goal of elucidating the underlying mechanisms and identifying potential therapeutic targets.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of migraine and primary headaches
2.2 Epidemiology of migraine
2.3 Pathophysiology of migraine
2.4 Genetic factors in migraine
2.5 Neurotransmitters involved in migraine
2.6 Imaging studies of migraine
2.7 Treatment options for migraine
2.8 Comorbidities of migraine
2.9 Animal models of migraine
2.10 Emerging therapies for migraine

Chapter 3: Research Methodology
3.1 Research design
3.2 Participant selection
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Ethical considerations
3.6 Sample size determination
3.7 Reliability and validity of measures
3.8 Statistical analysis

Chapter 4: Discussion of Findings
4.1 Analysis of research results
4.2 Comparison with existing literature
4.3 Implications of findings
4.4 Future research directions
4.5 Limitations of the study
4.6 Practical implications
4.7 Theoretical implications
4.8 Recommendations for clinical practice

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Contribution to the field
5.3 Implications for future research
5.4 Conclusion

Thesis Overview on Neurobiology of Migraine and Primary Headaches

Migraine is a prevalent and debilitating neurological disorder that affects a significant portion of the global population. Despite its widespread impact, the neurobiological mechanisms underlying migraine remain poorly understood. This thesis seeks to address this gap in knowledge by exploring the neurobiology of migraine and primary headaches.

Chapter 1 provides an introduction to the topic, outlining the background of the study, problem statement, objectives, limitations, scope, significance, structure of the thesis, and definition of terms. Chapter 2 reviews the existing literature on migraine and primary headaches, covering epidemiology, pathophysiology, genetic factors, neurotransmitters, imaging studies, treatment options, comorbidities, and emerging therapies.

Chapter 3 details the research methodology, including research design, participant selection, data collection methods, data analysis techniques, ethical considerations, sample size determination, reliability and validity of measures, and statistical analysis. Chapter 4 discusses the findings of the study, analyzing research results, comparing with existing literature, discussing implications, suggesting future research directions, addressing limitations, and providing recommendations for clinical practice.

Chapter 5 concludes the thesis, summarizing key findings, highlighting contributions to the field, discussing implications for future research, and offering a comprehensive conclusion. Overall, this thesis aims to advance our understanding of the neurobiology of migraine and primary headaches, with the hope of identifying new therapeutic targets and improving treatment outcomes for individuals suffering from these conditions.

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