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Introduction

Detection and analysis of drugs and poisons in biological samples by mass spectrometry is a crucial field in forensic toxicology and clinical pharmacology. Mass spectrometry is a powerful analytical technique that allows for the identification and quantification of a wide range of compounds in complex biological matrices. The ability of mass spectrometry to provide high sensitivity and specificity makes it an invaluable tool for the detection of drugs and poisons in biological samples.

This thesis aims to explore the current methodologies and techniques used in the detection and analysis of drugs and poisons in biological samples by mass spectrometry. The study will investigate the challenges and limitations faced in this field, as well as the potential for future advancements in technology and methodology. The significance of this research lies in its potential to improve the accuracy and efficiency of drug detection in forensic and clinical settings.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 History of mass spectrometry in drug analysis
2.2 Principles of mass spectrometry
2.3 Applications of mass spectrometry in forensic toxicology
2.4 Challenges in drug detection by mass spectrometry
2.5 Recent advancements in mass spectrometry technology
2.6 Comparison of mass spectrometry with other analytical techniques
2.7 Standardization in mass spectrometry analysis
2.8 Quality control and assurance in mass spectrometry
2.9 Interpretation of mass spectrometry data
2.10 Future trends in mass spectrometry analysis

Chapter 3: Research Methodology
3.1 Selection of biological samples
3.2 Sample preparation techniques
3.3 Instrumentation and analysis parameters
3.4 Calibration and validation methods
3.5 Data acquisition and processing
3.6 Method optimization
3.7 Quality control and assurance measures
3.8 Case studies and applications
3.9 Ethical considerations

Chapter 4: Discussion of Findings
4.1 Comparison of different mass spectrometry techniques
4.2 Evaluation of method sensitivity and specificity
4.3 Identification of challenges in drug detection
4.4 Discussion of potential solutions and improvements
4.5 Interpretation of research results
4.6 Implications for forensic and clinical practice
4.7 Recommendations for future research
4.8 Conclusion

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Recommendations for future research
5.3 Limitations of the study
5.4 Conclusion

This thesis will provide a comprehensive overview of the current state of research in the detection and analysis of drugs and poisons in biological samples by mass spectrometry. By examining the methodologies, challenges, and potential advancements in this field, this research aims to contribute to the improvement of drug detection practices in forensic and clinical settings.

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