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Introduction

Neurodegenerative disorders are a group of diseases characterized by the progressive degeneration of the structure and function of the nervous system. These disorders, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS), pose a significant health challenge worldwide. Despite extensive research efforts, the exact mechanisms underlying these disorders remain poorly understood. One emerging area of interest in the field of neurodegeneration is the role of extracellular vesicles (EVs) in disease pathogenesis.

EVs are small, membrane-bound particles released by cells that play a crucial role in intercellular communication. Recent studies have implicated EVs in various physiological and pathological processes, including inflammation, immune regulation, and cancer progression. In the context of neurodegenerative disorders, EVs have been shown to carry a diverse array of cargo, including proteins, nucleic acids, and lipids, that can influence the functioning of recipient cells in the brain.

This thesis aims to explore the role of EVs in the pathogenesis of neurodegenerative disorders. By investigating the content and function of EVs in the context of these diseases, we hope to gain a better understanding of the mechanisms underlying neurodegeneration and identify potential therapeutic targets for intervention.

Table of Contents

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Overview of neurodegenerative disorders
2.2 Extracellular vesicles: biogenesis and function
2.3 The role of EVs in neurological diseases
2.4 EV cargo in neurodegenerative disorders
2.5 EVs as biomarkers for disease
2.6 EV-based therapeutic strategies
2.7 EV isolation and characterization methods
2.8 Challenges in studying EVs in the brain
2.9 Emerging technologies for EV research
2.10 Gaps in current knowledge

Chapter 3: Research Methodology
3.1 Study design
3.2 Sample collection and processing
3.3 EV isolation and characterization
3.4 Cargo analysis
3.5 Functional assays
3.6 Animal models
3.7 Statistical analysis
3.8 Ethical considerations

Chapter 4: Discussion of Findings
4.1 EV cargo profiles in neurodegenerative disorders
4.2 Functional effects of EVs on target cells
4.3 Implications for disease pathogenesis
4.4 Potential therapeutic targets
4.5 Comparison with existing literature
4.6 Future directions
4.7 Limitations of the study
4.8 Conclusion

Chapter 5: Conclusion and Summary
5.1 Summary of findings
5.2 Implications for the field
5.3 Recommendations for future research
5.4 Conclusion

Thesis Overview

Neurodegenerative disorders represent a significant public health concern, with millions of individuals worldwide affected by these devastating diseases. While extensive research efforts have been dedicated to unraveling the underlying mechanisms of neurodegeneration, much remains to be understood. In recent years, extracellular vesicles (EVs) have emerged as key players in intercellular communication within the central nervous system, raising the possibility that these tiny vesicles could play a role in the pathogenesis of neurodegenerative disorders.

This thesis seeks to explore the role of EVs in neurodegeneration, focusing on their cargo content, functional effects on recipient cells, and potential as biomarkers and therapeutic targets for these diseases. By conducting a comprehensive literature review, employing state-of-the-art research methodologies, and analyzing our findings in the context of existing knowledge, we aim to shed light on the complex interplay between EVs and neurodegenerative disorders.

Through this thesis, we hope to contribute to the growing body of evidence implicating EVs in neurodegeneration and provide insights that may pave the way for the development of novel diagnostic tools and therapeutic strategies for these debilitating conditions. It is our belief that a deeper understanding of the role of EVs in neurodegenerative disorders will not only advance the field of neurodegeneration research but also offer hope for improved patient outcomes in the future.

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