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Introduction

Pulmonary Arterial Hypertension (PAH) is a severe and life-threatening condition characterized by elevated blood pressure in the arteries of the lungs, leading to right heart failure and ultimately death if left untreated. Current treatment options for PAH are limited and often associated with significant side effects, highlighting the need for more effective and safer therapies.

The development of small molecule inhibitors targeting specific pathways involved in the pathogenesis of PAH has shown promising results in preclinical studies. In this thesis, we aim to evaluate the efficacy and safety of a novel small molecule inhibitor for the treatment of PAH. This research has the potential to provide valuable insights into the development of targeted therapies for this debilitating disease.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Pathophysiology of Pulmonary Arterial Hypertension
2.2 Current Treatment Strategies for PAH
2.3 Small Molecule Inhibitors in PAH Therapy
2.4 Mechanism of Action of Small Molecule Inhibitors
2.5 Preclinical Studies on Small Molecule Inhibitors for PAH
2.6 Clinical Studies on Small Molecule Inhibitors for PAH
2.7 Safety and Tolerability of Small Molecule Inhibitors
2.8 Challenges in PAH Therapy
2.9 Future Directions in PAH Treatment
2.10 Gaps in the Literature

Chapter 3: Research Methodology
3.1 Study Design
3.2 Participants
3.3 Intervention
3.4 Outcome Measures
3.5 Data Collection
3.6 Data Analysis
3.7 Ethical Considerations
3.8 Timeline

Chapter 4: Discussion of Findings
4.1 Efficacy of the Novel Small Molecule Inhibitor
4.2 Safety Profile of the Novel Small Molecule Inhibitor
4.3 Comparison with Existing Therapies
4.4 Adherence and Tolerability of Treatment
4.5 Impact on Quality of Life
4.6 Mechanistic Insights
4.7 Subgroup Analyses
4.8 Limitations of the Study

Chapter 5: Conclusion and Summary
5.1 Summary of Findings
5.2 Implications for Clinical Practice
5.3 Recommendations for Future Research
5.4 Conclusion

Thesis Overview:

Pulmonary Arterial Hypertension (PAH) is a debilitating and life-threatening condition characterized by elevated blood pressure in the arteries of the lungs, leading to right heart failure and ultimately death if left untreated. Current treatment options for PAH are limited and often associated with significant side effects, highlighting the need for more effective and safer therapies.

The development of small molecule inhibitors targeting specific pathways involved in the pathogenesis of PAH has shown promising results in preclinical studies. In this thesis, we aim to evaluate the efficacy and safety of a novel small molecule inhibitor for the treatment of PAH. This research has the potential to provide valuable insights into the development of targeted therapies for PAH and improve outcomes for patients with this devastating disease.

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