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Introduction

Autophagy is a highly conserved cellular process that plays a crucial role in maintaining cellular homeostasis by degrading damaged organelles and proteins, and by recycling cellular components. Emerging evidence suggests that autophagy also plays a significant role in the development of drug resistance in infectious diseases. Understanding the molecular mechanisms underlying the role of autophagy in drug resistance is critical for the development of new therapeutic strategies to combat infectious diseases.

This thesis aims to explore the role of autophagy in the development of drug resistance in infectious diseases. The study will investigate how autophagy contributes to the survival of pathogens in the presence of antimicrobial agents, and whether targeting autophagy pathways can enhance the efficacy of existing antimicrobial therapies. By elucidating the mechanisms by which autophagy promotes drug resistance, this research seeks to identify novel drug targets for the treatment of infectious diseases.

Chapter 1: Introduction

1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review

2.1 Overview of autophagy
2.2 Autophagy and drug resistance
2.3 Role of autophagy in bacterial infections
2.4 Role of autophagy in viral infections
2.5 Role of autophagy in parasitic infections
2.6 Autophagy inhibitors as potential therapeutics
2.7 Autophagy inducers as potential therapeutics
2.8 Current strategies to overcome drug resistance
2.9 Autophagy modulation in combination therapy
2.10 Future directions in autophagy research

Chapter 3: Research Methodology

3.1 Study design
3.2 Cell culture and infection assays
3.3 Drug treatment assays
3.4 Autophagy assays
3.5 Molecular biology techniques
3.6 Statistical analysis
3.7 Ethical considerations
3.8 Data interpretation

Chapter 4: Discussion of Findings

4.1 Role of autophagy in drug resistance
4.2 Mechanisms of autophagy in pathogen survival
4.3 Targeting autophagy for drug development
4.4 Synergistic effects of combining autophagy modulation with antimicrobial therapies
4.5 Implications for clinical practice
4.6 Challenges and future directions

Chapter 5: Conclusion and Summary

In conclusion, this thesis will provide valuable insights into the role of autophagy in the development of drug resistance in infectious diseases. By investigating the mechanisms by which autophagy promotes drug resistance, this research aims to identify novel therapeutic targets for the treatment of infectious diseases. The findings of this study may have significant implications for the development of novel antimicrobial strategies that can effectively combat drug-resistant pathogens.

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