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Introduction

Obesity has become a major public health concern worldwide, with rates continuing to rise dramatically in recent years. While the traditional view of obesity has focused on a combination of genetic predisposition and environmental factors, emerging research suggests that epigenetic modifications may also play a significant role in the development and progression of obesity. Epigenetic modifications refer to changes in gene expression that are not caused by alterations in the DNA sequence itself, but rather by modifications to the structure of the DNA or the proteins associated with it.

This thesis aims to explore the role of epigenetic modifications in obesity, with a particular focus on how these modifications may contribute to the development and progression of the condition. By understanding the mechanisms through which epigenetic changes can influence obesity, we may be able to identify new therapeutic targets and interventions for the prevention and treatment of this growing health problem.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Overview of obesity
2.2 Genetic and environmental factors contributing to obesity
2.3 Introduction to epigenetics
2.4 Epigenetic modifications and obesity
2.5 Role of DNA methylation in obesity
2.6 Role of histone modifications in obesity
2.7 Role of non-coding RNAs in obesity
2.8 Epigenetic changes in adipogenesis
2.9 Epigenetic changes in appetite regulation
2.10 Epigenetic modifications as potential therapeutic targets for obesity

Chapter 3: Research Methodology
3.1 Research design
3.2 Study population
3.3 Data collection methods
3.4 Data analysis methods
3.5 Ethical considerations
3.6 Validity and reliability
3.7 Limitations of the study
3.8 Future research directions

Chapter 4: Discussion of Findings
4.1 Overview of findings
4.2 Relationship between epigenetic modifications and obesity
4.3 Potential mechanisms underlying epigenetic regulation of obesity
4.4 Implications of findings for the prevention and treatment of obesity
4.5 Challenges and future directions for research in this area

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Conclusions
5.3 Contributions to the field
5.4 Recommendations for future research
5.5 Implications for public health

Thesis Overview

Obesity is a complex and multifactorial condition that is influenced by a combination of genetic, environmental, and epigenetic factors. While the traditional view of obesity has focused on genetic predisposition and environmental influences such as diet and exercise, emerging research suggests that epigenetic modifications may also play a significant role in the development and progression of obesity.

This thesis aims to explore the role of epigenetic modifications in obesity, with a particular focus on how these modifications may contribute to the development and progression of the condition. By conducting a comprehensive review of the literature and analyzing primary data, this thesis seeks to elucidate the mechanisms through which epigenetic changes can influence obesity and identify potential therapeutic targets for the prevention and treatment of this growing health problem.

Through a detailed exploration of the current state of knowledge on epigenetic modifications in obesity, this thesis aims to make a significant contribution to the field of obesity research and provide valuable insights for future studies and interventions aimed at addressing this global health issue.

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